A productive two-day workshop was held to outline the research objectives of RobustNature in a transdisciplinary manner. Researchers from RobustNature at Goethe University Frankfurt and associated research centres, as well as key stakeholders from governmental and non-governmental sectors, participated. The work was conducted in small groups and collaboratively to explore strategic research topics for Germany, particularly the Frankfurt region, concerning chemical pollution, its impact on biodiversity, and the necessary transformations to mitigate these impacts.